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大学院研究教育概要から抜粋


◆研究の狙い
設計された生理活性物質や,構造や活性が未知の天然有機化合物を新規な方法で合成して供給するとともに実用的で有効な物質変換法を確立すること。

私たちのつくっている色々な生理活性物質

◆研究の方法
生体分子として興味深い性質を持つ特定の有機化合物を標的として合成計画を立て,それを実行する。その課程で生じる予見不能な問題を克服しながら,一般的に利用できる合成の方法論を確立する。
◆教育の狙い
実験の意図,操作の意味,データの解釈を充分理解して研究を行い,高度な実験技術を習得し,化学的なものの見方を身につけること。

主な論文

"New naphthoquinone and monoterpenoid from Plumbago zeylanica"
Tetrahedron Lett., 2014, 55, 6554-6556.

"New chalcone dimers from Caesalpinia ferrea Mart act as potent inhibitors of DNA topoisomerase II"
Tetrahedron Lett., 2013, 49, 4516-4518.

"Culcitiolides A-D, four new eremophilane-type sesquiterpene derivs. from Senecio culcitioides"
Natural Product Communications , 2012, 54, 5052-5055.

"Total synthesis of cleomiscosin C via a regioselective cycloaddition reaction of o-quinone"
Tetrahedron Lett., 2008, 49, 4516-4518.

"Reversal of the regioselectivity in a cycloaddition of o-quinones by varying the position of alkoxy substituents"
Tetrahedron Lett., 2008, 49, 2558-2561.

"Total synthesis of (+-)-nitidanin and novel procedures for determination of the location of the side chains on 1,4-benzodioxane"
Tetrahedron Lett., 2007, 48, 771-774.

"Total synthesis and absolute stereochemistry of plakortone E "
Tetrahedron Lett., 2006, 47, 2287-2290.

"Stereocontrolled Synthesis of (+-)-methyl 3,6-epoxy-4,6,8-triethyl-2,4,9-dodecatrienoate, a major metabolite of Caribbean sponge, Plakortis halichondrioides, using reactions of alkylidenecarbenes in one pot "
Tetrahedron Lett., 2005, 46, 7483-7485.

"Stereocontrolled synthesis of the aminocyclitol moiety of (+)-trehazolin via C-H insertion reaction of alkylidenecarbene "
Tetrahedron Lett., 2004, 45, 4545-4548.

"Concise synthesis of 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) as a protected form based on a new transformation of alfa,beta-unsaturated ester to alfa-oxocarboxylic acid ester via diol cyclic sulfite"
Tetrahedron Lett., 2004, 45, 7133-7136.

"Synthesis and structure of diastereomers of pentenocin B produced by Trichoderma hamatum FO-6903"
Tetrahedron Lett., 2004, 45, 1639-1641.

"Total Synthesis of (±)-Aiphanol, a Novel Cyclooxygenase-inhibitory Stilbenolignan"
Chem. Lett, 2003, 32, 420-421.

"Total synthesis of sporochnols, fish deterrents from a marine alga"
Tetrahedron Lett., 2002, 43, 4641-4644.

"Stereoselective Synthesis of (1S, 3R)-1-Aminocyclopentane-1,3-dicarboxylic Acid via C-H Insertion of Alkylidnecarbene"
Biosci. Biotechnol. Biochem., 2002, 66(4), 887-891.

" First Synthesis of Subelliptenone F, an Inhibitor of Topoisomerase II"
Chem. Lett. 2000, 464-5.

"Synthesis of (-)-Malyngolide Using Reactions of Alkylidenecarbenes"
J. Chem. Soc., Parkin Trans. I, 1998, 293-7.

"Sesquiterpenoids from Cyperous Rotundus"
Phytochemistry, 1998, 47, 577-81.

"Synthesis of (-)-Gleenol via C-H Insertion Reaction of Alkylidenecarbene"
Chem. Lett., 1998, 739-40.

"Synthesis of (-)-neplanocin A via C-H insertion of alkylidenecarbene"
Tetrahedron Lett., 1995, 36, 1537-8.

"Synthesis of tertiary alcohol from secondary alcohol via intramolecular C-H insertion of alkylidenecarbene "
Tetrahedron Lett., 1995, 36, 3375-6.

"Generation of alpha -alkoxycarbonyl alkylidenecarbenes: synthesis of t-butyl cyclopentenecarboxylates"
Tetrahedron Lett., 1995, 36, 8843-4.

"Novel synthesis of (-)-malyngolide using reactions of alkylidene carbenes"
J. Chem. Soc., Chem. Commun., 1993, 47, 1299-1300.

"Generation of alkylidenecarbenes by the alkenation of carbonyl compounds with lithiotrimethylsilyldiazomethane"
J. Chem. Soc., Chem. Commun. , 1992, , (9), 721-2.

"Absolute structure of (-)-4,5-trans-dihydroxy-3-methyl-2-cyclopentenone isolated from the marine alga, Grateloupia filicina (Wulfen) J. Agardh by the synthesis of both enantiomers"
Agric. Biol. Chem. FIELD Full Journal Title:Agricultural and Biological Chemistry, 1991, 55, 2437-8.

"Carbon-hydrogen insertion method for the chiral tertiary alcohol: formal synthesis of (-)-frontalin"
Tetrahedron Lett. , 1990, 31., 1039-40.

" Methanolysis of dimethyl (1-diazo-2-oxopropyl)phosphonate: generation of dimethyl (diazomethyl)phosphonate and reaction with carbonyl compounds"
Synth. Commun., 1989, 19, 561-4.


岡山理科大学 生物化学科